138 / 210
S130
Poster presentations / European Geriatric Medicine 6S1 (2015) S32
–
S156
acid and EIDV was attenuated but was statistically significant in
Model 2 (−0.32
±
0.17, P = 0.056).
Conclusions:
In older women, but not in men, uric acid is negatively
and independently associated with EIDV, suggesting its role as
surrogate metabolic marker rather than determinant of endothelial
function in older individuals.
P-367
Impact of switching from a Brand to a Generic macrogol on
prescriptions and doses for patients with chronic constipation
in the UK
S. Shehla
1
, V. Bajaj
1
, A. Naidoo
1
1
Norgine Ltd, Uxbridge, United Kingdom
Objectives:
To compare prescription numbers and doses
(20 sachets/pack) for chronic constipation patients switched from
branded macrogol (MOVICOL) to generic macrogol (LAXIDO), and
those who switched back.
Methods:
Retrospective real-world, longitudinal patient and
prescribing data from 397 UK GP practices (2,186 GPs,
13,567 patients; January–December 2013; CSD-division of IMS
Health) were analysed in two cohorts of chronic constipation
patients: (1) patients prescribed branded macrogol, switched to
generic; (2) patients prescribed branded macrogol, switched to
generic (Switch-1) and returned to the brand (Switch-2). All
patients were tracked from initiation to treatment end. Annualised
prescriptions and doses/patient changes in each cohort were
analysed (one- and two-sided t-test for two-sample assuming
unequal variances).
Results:
Males/females aged ≥13 years were analysed. In cohort (1),
N = 3109, M= 0.63, SD = 8.29, prescription numbers (+8%) and
doses (+13%) per patient/year showed an average increase.
Absolute increase in prescription numbers (+0.6) and doses (+1.7)
were significant (p
<
0.05), and observed across all age groups
(elderly [65+], middle-aged [36–64], young adult [19–35],
adolescent [13–18]). In cohort (2), N = 91, M= −3.41, SD = 1.65,
prescription numbers (−24%) and doses (−11%) per patient/year
showed an average reduction during Switch-2. Additionally,
absolute increase in prescription numbers (+5.0) and doses (+4.9)
at Switch-1 was significant (p
<
0.05).
Conclusions:
Chronic constipation patients switched from branded
to generic macrogol required a significantly higher number of
prescriptions and doses than previously required. Patients who
switched back from the generic to the branded macrogol required
fewer. Factors impacting changes in prescription e.g. efficacy,
convenience, and compliance require further investigation.
Analysis was funded by Norgine.
P-368
Metabolical and functional characteristics of octogenarian
men using statins
T. Strandberg
1
, T. Pienim¨aki
2
, A. Strandberg
1
, K. Pitk¨al¨a
1
, R. Tilvis
3
1
University of Helsinki, Helsinki, Finland;
2
Kela, Oulu, Finland;
3
Helsinki Unversity Central Hospital, HUS, Finland
Objectives:
Despite lack of clear trial evidence, statins are
increasingly started in older patients and there are recent concerns
about adverse effects on glucose metabolism. We compared
octogenarian statin users and nonusers.
Methods:
In the Helsinki Businessmen Study (socioeconomically
homogenous group of men born in 1919–1934, n = 3309) clinical
data are available from midlife to old age. A random subgroup of
survivors participated in clinical studies in 2010/11 (n = 527), and
there were 255 and 261 statin users and nonusers, respectively. All
men were homeliving and mean age in groups was 83 years.
Results:
Older statin users had had significantly higher cholesterol
level than nonusers (6.7 vs. 6.1mmol/L, P
<
0.001) already in
midlife, but in a majority statin had been started in old age; only
26% had used a statin
>
10 years. Current mean LDL cholesterol
levels were 2.3 and 3.0mmol/L (P
<
0.001) among statin users
and nonusers, respectively. There were no differences in BMI
nor functional variables including MMSE, walk speed, handgrip
strength and peak expiratory flow between users and nonusers.
Of laboratory variables, creatinine, urate, glucose and homeostatic
model assessment-insulin resistance (HOMA-IR) index were higher,
and quantitative insulin sensitivity check index (QUICKI), and HDL
cholesterol lower among statin users. Nutrition marker prealbumin
was significantly increased (P
<
0.001) among statins users and it
was independent of BMI.
Conclusions:
While no functional differences were noted between
octogenarian statin users and nonusers, users had signs of impaired
glucose but better nutritional status. Metabolic effects of statins in
older people may be complex.
P-369
nutritionDay in nursing homes
–
Nutritional strategies for
residents with dysphagia
M. Streicher
1
, M. Themessl-Huber
2
, M. Mouhieddine
2
, S. Kosak
3
,
R.E. Roller
4
, K. Schindler
2
, C.C. Sieber
5
, M. Hiesmayr
2
, D. Volkert
6
1
Friedrich-Alexander University Erlangen-N¨urnberg, Nuremberg,
Germany;
2
Medical University of Vienna, Vienna, Austria;
3
NutritionDay office, Vienna, Austria;
4
Medical University of
Graz, Graz, Austria;
5
Friedrich-Alexander Universit¨at Erlangen-
N¨urnberg, Nuremberg, Germany;
6
Friedrich-Alexander-Universit¨at
Erlangen-N¨urnerg, N¨urnberg, Germany
Objective:
Dysphagia complicates oral nutrition (ON) and often
requires alternative feeding routes. The aim was to determine
nutritional strategies for nursing home (NH) residents with
dysphagia compared to residents without dysphagia.
Methods:
NH residents participating in the nutritionDay project
(2007–2013) with complete data on dysphagia and nutritional
strategy were included (N = 27,361). Information on different kinds
of nutritional strategies [ON, oral nutritional supplements (ONS),
tube-feeding, parenteral nutrition (PN)] was combined and
prevalence rates calculated for residents with and without
dysphagia.
Results:
Prevalence of dysphagia was 13.7%. Almost all residents
without dysphagia (98.7%) received ON solely, including 77.0% with
normal, 6.7% with unknown, 5.3% with texture-modified, 2.3% with
enriched diets, and 7.4% with ON plus ONS. The remaining 1.3%
received ON plus tube-feeding or ON plus PN. Of all residents
with dysphagia, 79.3% received ON solely, including 24.3% with
normal, 3.0% with unknown, 29.1% with texture-modified, 3.9%
with enriched diets, and 19.0% with ON plus ONS. 18.5% received
tube-feeding, including 8.0% with solely tube-feeding, 10.2% with
tube-feeding plus ON, and 0.3% with tube-feeding plus PN. The
remaining residents either received total PN (0.7%) or PN plus ON
(1.5%). Modified ON, ON plus ONS, and artificial nutrition were all
significantly more frequent in residents with dysphagia (Chi
2
-Test,
p
<
0.05, Bonferroni correction).
Conclusion:
In NH participating in the nutritionDay, most prevalent
nutritional strategies for residents with dysphagia were texture-
modified and normal diets, ON plus ONS, ON plus tube-feeding,
and tube-feeding alone.
*Medical Nutrition International Industry supported the realization
of this analysis.