European Geriatric Medicine - Supplement 1 - Volume 6

Poster presentations / European Geriatric Medicine 6S1 (2015) S32

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S156

S49

of total edentulism, caries and periodontal disease were 46%, 24%

and 21%, respectively. There was a higher ATn in patients with

better cognitive function [normal cognition (NC) 7.68 vs MCI 5.83 vs

Dementia 4.42, ns). There was a lower prevalence of caries (NC 22.7

vs cognitively impaired 25.8%, ns) and periodontal disease (NC 19.7

vs cognitively impaired 22.6%, ns) in patients with better cognition.

Although cognitively impaired patients presented lower ATn, the

usage of dental prosthesis was similar in cognitively preserved

and impaired patients (36.4% vs 35.5%). Malnutrition was more

prevalent among cognitive impaired patients (74.2% vs 66.7%).

Conclusions:

Cognitive impairment is associated with poorer OHS.

Difficulty in oral hygiene must be assessed as it might justify poorer

OHS and contribute to malnutrition.

P-064

Vitamin B12, folate and depression evaluated with geriatric

depressive scale (GDS) in elderly with dementia

G. Fabio

, S. Perna

, A. Miccono

, C. Bologna

, G. Peroni

, D. Guido

F. Guerriero

, C. Sgarlata

, M. Rondanelli

Azienda di Servizi alla Persona, S. Margherita Institute, Pavia, Italy;

University of Pavia, Pavia, Italy

Objectives:

Several nutrients may have preventive/ameliorative

roles in depression. Previous studies have shown conflicting results

on the deficiency of vitamin B12, homocysteine and folic acid are

associated with depression.

This study investigated the association among folate, B12, and

depressive symptoms in elderly Italian populations with mild

cognitive impairment.

Methods:

The study was a cross-selectional study conduced on

35 elderly (mean 80.72: ds 7.71) subjects (24 females, 11 males)

with Mini Mental State Examination (19.5

1.5). Laboratory values

of folate, vitamin B12 were examined for their independent

relationship with depressive symptoms [Geriatric Depression Scale

(GDS) score ≥5].

Results:

The regression model showed only one significant evidence

for the effect of vitamin B12 levels on GDS (B = −0.003; P

0.05).

A relevant association but no significant between folic acid and

geriatric depression scale was found (B = −0.56; P = 0.278).

Conclusion:

Decreasing and low levels of folate and deficient levels

of B12 were associated with greater risk of depressive symptoms

in elderly Italian with dementia.

Vitamin B12 plays a protective rule in the progression of depression.

In this way a supplementation can be fitting in the prevention of

symptoms.

P-065

Feasibility of the cross-cultural dementia screening

M.C. Faes

, S. Koot

, H. Scholten

TweeSteden Hospital, Tilburg, Netherlands

Introduction:

In the Netherlands the number of elderly immigrants

with dementia is growing. Language barriers and illiteracy

are obstacles in intercultural dementia diagnostics. Recently, a

neuropsychological test that overcomes these obstacles, the Cross-

Cultural Dementia Screening (CCD), became available. The CCD

is a neuropsychological screening to detect cognitive disorders

indicative for dementia. This pilot study evaluates the feasibility

of the CCD in a geriatric outpatient clinic of a teaching hospital.

Methods:

This study was conducted in all, not-Dutch speaking,

patients,

55 years, who consulted the outpatient clinic because of

cognitive complaints, between December 2014 and March 2015. The

geriatrician decided if assessment with the CCD by a well-trained

neuropsychologist was needed. Feasibility was tested by timing the

duration of the administration of the CCD and by interviewing the

psychologist and patients about their experiences.

Results:

7 patients were included, 2 patients completed the CCD,

within 40 minutes. The results of the CCD distinguished between

MCI and dementia in these patients. In 5 patients the diagnosis of

dementia was clinically obvious, further neuropsychological testing

had no added value. Administration of the CCD is complex, different

tasks need to be done simultaneously, apart from observing the

patient. A caregiver is still needed to interpret the goal of the test.

Both patients appreciated to be tested in their native language.

Conclusion:

These findings suggest that the CCD is suitable to

use in elderly immigrants with a diagnostic dilemma concerning

cognitive impairments. Motivated patients, involved caregivers and

a well-trained neuropsychologist are prerequisites for testing.

P-066

Vitamin D deficiency reduces the clinical response to

memantine in older adults presenting with moderate to severe

Alzheimer’s disease

A. Giusti

, C. Prete

, B. Senesi

, E. Palummeri

, A. Barone

A. Pilotto

Department of OrthoGeriatrics, Rehabilitation and Stabilization

–

Frailty Clinic

–

Galliera Hospital, Genoa, Italy;

Galliera Hospital,

Genoa, Italy;

Italy

Objectives:

To determine whether vitamin D status affects clinical

response to memantine in elderly with moderate-severe Alzheimer

disease.

Methods:

We considered 49 community-dwelling older adults,

aged ≥70 years, presenting with moderate-severe Alzheimer dis-

ease, starting memantine and not receiving vitamin D supplements.

The following data were collected: age, gender, baseline functional

status (basic and instrumental activities of daily living), baseline

25-hydroxyvitamin D serum concentration (25OHD), baseline and

6-month Mini Mental State Examination score (MMSE). Patients

were stratified according to 25OHD in two groups: ≤10 and

10 ng/ml. The primary outcomes compared between two groups

were: absolute change of MMSE and proportion of patients who

gained at least one point of MMSE at 6-month.

Results:

Mean

SD age was 80.6

5.1 years, 10 patients were

men and mean

SD MMSE score was 14.3

4.7. The 57.1% of

patients presented with 25OHD ≤10 ng/ml. The two groups defined

according to 25OHD had similar baseline characteristics. After

six months of memantine, absolute change (

SD) of MMSE was

−0.6

3.3 in patients with 25OHD ≤10 ng/ml and +2.0

2.9 in

those with 25OHD

10 ng/ml (p = 0.011). When we considered the

proportion of subjects who gained at least one point of MMSE, the

respective figures were 35.7% (≤10 ng/ml) and 66.7% (

10 ng/ml;

p = 0.045). A positive correlation between 25OHD and absolute

MMSE change was found: Spearman r = 0.436 (p = 0.001).

Conclusions:

Severe vitamin D deficiency is associated with poor

clinical response to memantine in moderate to severe Alzheimer

disease. If confirmed these data support vitamin D supplementation

during memantine treatment to optimize clinical response.

P-067

Hyponatremia due to SIADH and dementia

B. de Almeida Marques

, A.M. Antunes

, S. Guerreiro Castro

F.G. Magalh˜aes

, V. Br ´as da Silva

, H.K. Gruner

, N. Riso

Hospital de Curry Cabral, Servi ¸co de Medicina 2, Lisboa, Portugal

Introduction:

Hyponatremia is a very common condition in

hospitalized elderly patients and SIADH is one of the most

important causes. Vascular dementia has emerged as one of the

leading health problems nowadays and is responsible for at least

20% of cases of dementia.

Methods:

Case 1: Male, 80 years old, dependent, admitted

for convulsive crisis, hyponatremia and pneumonia. Medical

history includes vascular encephalopathy with epilepsy and

ischemic and hypertensive cardiopathy. Laboratory findings: seric

Na 112 meq/L; seric osmolality 234 mOsmol/kg; urinary Na

108 mEq/L. Case 2: Female, 82 years old, admitted for severe