54 / 210
S46
Poster presentations / European Geriatric Medicine 6S1 (2015) S32
–
S156
We concluded that in aged males, the high levels of testicular
estradiol caused a constant negative feedback of gonadotrophin
release and testosterone production. This conclusion was enforced
by removing the negative feedback due to estodial by use of an
anti-estrogen, clomiphene citrate.
P-053
Telomere attrition during old age can’t explain the relation
between short telomere and atherosclerosis
S. Toupance
1
, G. Watfa
2
, C. Lakomy
1
, A. Kearney-Schwartz
3
,
C. Labat
4
, P. Rossignol
5
, P. Lacolley
1
, F. Zannad
5
, A. Benetos
2
1
INSERM U1116, Vandoeuvre-l`es-Nancy, France;
2
France;
3
University
Hospital of Nancy, Vandoeuvre-l`es-Nancy, France;
4
Inserm
U 1116, Vandoeuvre-l`es-Nancy, France;
5
CIC-P Pierre Drouin,
Vandoeuvre-l`es-Nancy, France
Objectives:
Short leukocyte telomere length (LTL) is associated
with atherosclerosis and diminished survival in the elderly. The
prevailing view is that LTL serves as a biomarker of cumulative
inflammation and oxidative stress during life. However since LTL
dynamics are mainly defined during the first 20 years of life, short
LTL could precede atherosclerosis and act more as a determinant.
We examined whether LTL attrition during old age can affect
individuals’ LTL ranking in relation to their peers and which clinical
or lifestyle factors can predict it.
Methods:
We measured LTL by Telomeric Restriction Fragment
Southern Blot in samples donated 8 years apart on average by 76
subjects aged 60 to 85 years.
Results:
Mean LTL attrition was 27 bp/year. No clinical or lifestyle
risk factors seem to exert significant effect on LTL attrition. We
observed a close relationship (r = 0.88) between baseline and
follow-up LTL values. Ranking individuals by LTL deciles revealed
that 87.5% showed no rank change or only one decile change over
time. We observed relations between values of LTL and BMI as well
as between LTL and carotid atheroma. No such relationship was
observed between LTL and smoking status or pulse wave velocity.
Conclusions:
In elderly people LTL ranking changes very little
over time. Accordingly, the links of LTL with atherosclerosis and
longevity appear to be established earlier in life. It is therefore
unlikely that lifestyle and its modification during old age exert a
major impact on telomere length that should be considered as an
independent risk factor.
Cognition and dementia
P-054
The increasing burden of dementia in Chile
C. Albala
1
, P. Fuentes
2
, L. Lera
3
, H. Sanchez
4
, B. Angel
3
, C. Marquez
3
1
Universidad de Chile, Santiago, Chile;
2
Fac of. Medicine University of
Chile, Santiago, Chile;
3
INTA, Universidad de Chile, Santiago, Chile;
4
INTA. University of Chile, Santiago, Chile
Background:
Chile is ageing rapidly with a consequent increase in
the frequency of chronic diseases, among which probably the most
devastating is dementia.
Objective:
To describe the prevalence of dementia and its
contribution to the burden of dependence in Chilean older people.
Design:
Cross-sectional survey, in a Chilean representative sample
of 4867 (63.2% women) community dwelling people ≥60 y selected
with a probabilistic, stratified, multi-stage sampling design.
Dementia was defined with a validated test consisting in MMSE
score
<
22 and Pffefer Activities Questionnaire score
>
5. Dependence
was defined as need of assistance for ≥1ADL/≥2IADL or dementia.
Results:
Total crude prevalence of dementia was 7.0% (women 7.7%;
men 5.9%; p = 0.15) yielding estimates of 181,761 cases of dementia
in Chile 2015 and 221,523 in 2020. Prevalence was higher in rural
than in urban sample (10.3% vs. 6.3%; p = 0.002) and increasing
the higher age reaching 32.6% in people ≥85 y old. A strong
association with education was observed being the prevalence
in illiterates 25.2% vs. 1.2% in people with ≥13 school years. The
fraction of dependence attributable to dementia was 32.6%. The age
and gender adjusted model for dementia showed association with
rurality (OR = 1.42; 95% CI 1.02–2.01) and low education (OR = 2.76;
95% CI 1.54–4.94).
Conclusion:
The growing number of people with dementia poses
a huge challenge to our country. It is imperative to anticipate the
demand for a particularly vulnerable group usually forgotten and
discriminated. Early detection and design of programmes aimed
to fight against reversible risk factors while stimulating protector
factors should be a priority for the public health policies in the
country
Funded by Fondecyt grant 1130947 & SENAMA
P-055
Sleep apnea syndrome, hypertension, CSF and dementia
J. Attier-Zmudka
1
, F. Gleize
2
, B. Berteaux
2
, Y. Douadi
2
, E. Colpart
2
,
S. Dao
2
, A.-S. Macaret
3
, I. Gyselinck
2
, J.-M. S ´erot
3
, O. Bal ´edent
4
1
Centre Hospitalier de Saint Quentin, Saint Quentin, France;
2
Saint
Quentin Hospital, Saint Quentin, France;
3
Saint Quentin Hospital,
Saint Quentin;
4
University Hospital of Amiens, Amiens, France
Objective:
To quantify the respiratory, cardiac or hemohydrody-
namic alterations in patients with dementia. Many authors show
the role of vascular factor. Likewise, that hypertension alters in
the CSF, the protein b ´eta42 rate, marker of Alzheimer Disease
(AD). Sleep apnea syndrome (SAS) promotes nocturnal elevations
of intracranial pressure. According to a recent study, Phase-Contrast
magnetic resonance imaging (PC-MRI) makes the differential
diagnosis between hydrocephalus, called “normal” pressure with
AD.
Methods:
21 patients aged 85
±
8 years, suffering from dementia,
with MMS average at 21
±
5 have been recruited in the geriatric
department of Saint Quentin Hospital (France). Each included
patient has a biological, neuropsychological and standardized
geriatric assessment, a blood pressure holter, polygraphy and PC-
MRI, in aim to calculate the stroke volume in the internal carotid
and vertebral arteries and quantify the oscillatory volumes of CSF
during the cardiac cycle.
Results:
•
2 patients did not stand the polygraphy. 15 of 19 included subjects
had sleep apnea, none of them had a pneumological history.
•
1 patient did not stand the blood pressure holter. 12 of 20
included subjects had known and treated hypertension and 11 of
these 12 also had SAS.
•
4 patients did not stand MRI, 4 of 17 included subjects had
altered LCS dynamic indicating an active hydrocephalus being
investigated and 3 patients showed impairment in cerebral
vascular flow.
Conclusion:
The systematic search of SAS and hemohydrodynamic
disorders in elderly patients with neurodegenerative pathology is
needed to better identify, understand and heal.
P-056
Telematic application for the cognitive valuation, diagnosis
and personalized intervention in cognitive impairment and
dementia
J.J. Calvo Aguirre
1
, M. Barandiaran Amilano
1
, O. Bueno Ya˜nez
2
,
M.I. Bag¨es Bafaluy
3
1
SESOSGI, San Sebastian, Spain;
2
Geriatric Nursing. Residencia Sagrado
Coraz´on, Paseo Gabierrota, Spain;
3
Saludnova, San Sebastian, Spain
Objectives:
Cognitive stimulation programs are developed for
rehabilitation of persons with impairment without considering the