151 / 210
Poster presentations / European Geriatric Medicine 6S1 (2015) S32
–
S156
S143
during hospitalitation and at discharge 16,000 IU once a month
and daily 800 IU vitamin D + calcium 1000mg. Patients with
vitamin D between 21 and 30 ng/ml received at discharge 16,000 IU
once a month and daily 800 IU vitamin D + calcium 1000mg.
Three months lather 106 patients (80.9%) had more than 30 ng/ml,
18 (13.7%) had between 20 and 30 ng/mL and 7 patients (5.3%) had
25OHD
<
20 ng/ml. Only 18 patients (14%) had SHPT.
Conclusions:
An intensive replenishment Vitamin D protocol
rapidly reduces the frequency of Vitamin deficit and correct the
SHPT in most cases.
P-414
Comparative analysis of the potentially inappropriate
medication in patients during their 1st geriatric appointment,
by Beers 2012 and STOPP/START criteria
M. Moraes
1
, M.A. Soares
2
, J. Gorjao Clara
3
1
Pharmacist Faculty of Lisbon, Lisbon, Portugal;
2
Faculty of Pharmacy
of Lisbon University, Portugal;
3
Faculty of Medicine, Lisbon University
and North Lisbon Hospital, Lisbon, Portugal
Introduction:
The risk of morbidity and mortality associated with
drug therapy in older people requires care to avoid the use of
potentially inappropriate medications (PIM). The optimization of
drug therapy by Beers 2012 and STOPP/START criteria can help in
reducing the use of PIM prescription improving therapeutic safety
in older people.
Objectives:
Characterize and compare PIM prescription in the older
people (≥65 years) in the first geriatric appointment.
Methods:
Descriptive study.Medication analysis of 100 patients, in
their first geriatric appointment through application of the Beers
2012 and STOPP/START criteria.
Results:
Patients’ media age was 80.6 years (65–92), most of them
were women (69%). The total number of diseases was 554 with a
mean of 5.54 per patient (2–12), total number of prescribed drugs
was 753 (media of 7.53 drugs/patient, drug limits for patient 0–16).
According to the 2012 Beers criteria, 54% of patients were taking
at least one PIM and 30% were taking drugs to be used with caution.
By STOPP criteria 48% of the patients were taking at least one PIM
and 15% of the patients were taking drug duplications. By START
criteria 10% of the patients weren’t taking any needed drugs.
Conclusions:
This study showed that either using Beers 2012 or
STOPP/START criteria, the studied patients were taking a high
number of inappropriate medications, drug duplications and missed
some needed drugs what reduces therapy safety. With the use of
any of these criteria health professionals would be able to avoid
PIM and to get better clinical outcomes for their old patients.
P-415
Pharmacological treatment of elderly subjects in Poland
–
PolSenior study
A. Neumann-Podczaska
1
, M. Mossakowska
2
, B. Wizner
3
,
K. Wieczorowska-Tobis
4
1
Geriatric and Gerontology Department, University of Medical
Sciences,Poznan, Poland, Poznan, Poland;
2
International Institute of
Molecular and Cell Biology, Warsaw, Poland, Poland;
3
Department of
Internal Medicine and Gerontology, Jagiellonian University, Medical
College, Cracow, Cracow, Poland;
4
Poznan University of Medical
Sciences, Poznan, Poland
Objectives:
The aim of the study was to describe qualitative and
quantitative aspects of pharmacotherapy of elderly individuals in
Poland.
Methods:
The analysis of pharmacotherapy was done among 4873
elderly individuals (F: 2345, M: 2519, average age: 79.3
±
8.69 (F –
79.2
±
8.86; M – 79.4
±
8.53).
Quantitative and qualitative analysis of pharmacotherapy was
done both in all analyzed group and within 5-years age cohorts
([1]: 65–69, [2]: 70–74, [3]: 75–79, [4]: 80–84, [5]: 85–89, [6]: 90+).
Regarding prescribed (Rp) and over the counter (OTC) drugs the
number of persons who did not take any drugs in the last week
and those who regularly consumed 1–5, 5+ or 10+ drugs was
calculated.
Results:
The average number of drugs (Rp+OTC) was 5.1
±
3.56 (F:
5.5
±
3.54 vs M: 4.8
±
3.55, p
<
0.001; age cohorts – 1: 4.2
±
3.32,
2: 4.9
±
3.54, 3: 5.3
±
3.47, 4: 5.7
±
3.62, 5: 5.5
±
3.57, 6: 5.3
±
3.66).
Regarding polypharmacy – 10.4% of all subjects (507 persons)
declared not to take any drugs (F: 7.5% vs M: 13.1%, p
<
0.001) while
46.7% (2277) took 1–5 drugs (F: 46.7% vs M: 46.9%, ns), 42.9% (2089)
>
5 drugs (F: 45.6% vs M: 40.3%, p
<
0.001), 7.3% (354)
>
10 drugs
(F: 8.3% vs M: 6.3%, p
<
0.01). The most prevalent group of drugs
taken were: musculoskeletal drugs (81.3% of all subjects; F: 77.4%
vs M: 85.0%, p
<
0.001), cardiovascular agents (75.0%; F: 80.0% vs
M: 70.3%, p
<
0.001), alimentary tract drugs (50.2%; F: 54.6% vs
M: 46.0%, p
<
0.001), central nervous system drugs (35.9%; F: 41.0%
vs M: 31.1%, p
<
0.001).
Conclusions:
The prevalence of polypharmacy among the elderly
subjects in Poland is high.
P-416
Identification and comparison of rates of inappropriate drugs
in elderly population
J. Geoffray-Emereau
1
, S. Henni
2
, G. Feinard
1
, S. Piessard
3
1
Pharmacy, Sevre&Loire Hospital, Vertou, France;
2
University Hospital
Center of Angers, Angers, France;
3
Pharmacy, Sevre&Loire Hospital,
Faculty of Pharmacy Nantes, Nantes, France
Objective:
Chronic polypharmacy for elderly people has been
published as potentially inappropriate due to several adverse
events. According to Beers and Laroche criteria and the new
recommendations of the management of high blood pressure in
elderly patients, we have aimed to realize a practice review.
Method:
Three reviews (on 2010, 2011 and 2014) were conducted
using the same assessment methodology on 50 prescriptions in
hospitalized elderly patients. We have used the Haute Autorit ´e
de Sant ´e tools with a list of falls inductors drugs (including anti-
psychotic, benzodiazepines, anticholinergic). In 2014 we have added
the new criteria: more than 1 diuretic (D) or 3 anti hypertensive
agents (AH) and absence of central anti-hypertensive drug (CAH).
Results:
The mean age of patients was 84
±
6 years; the average
number of items prescribed per patient was 12
±
4 drugs. In 2014
the ratio of inappropriate drugs prescriptions was 12% and the
prescriptions containing more than 2 psychotropic drugs also 12%.
Benzodiazepines with long half-life were prescribed in 12% and
they were used as antiepileptic in 66%. Drugs with anticholinergic
properties were prescribed in 12%. Only 2 patients exhibited
inappropriate prescription with D, AH and CAH drugs.
Conclusion:
The inappropriate drugs prescriptions decreased in
2014 in comparison to 2011 (22%) and 2010 (18%). Our 2014
practice review teaches us that the chronic polypharmacy still a
real challenge in elderly patients. A handy booklet entitled “Memo
of best practice of medicinal prescription at the elderly person” has
been created and shared to the medical team.
P-417
Potentially harmful drugs and 3.5-year mortality in all
institutional residents in Helsinki
K. Pitk¨al¨a
1
, H. Soini
2
, S. Muurinen
3
, M. Suominen
4
, N. Savikko
5
1
University of Helsinki, University of Helsinki, Finland;
2
City
of Helsinki, Helsinki, Finland;
3
STAKES National Research and
Development Centre For Welfare and Health, Helsinki, Finland;
4
Finland;
5
Espoo City, University of Helsinki, Finland
Background:
Antipsychotics have been suggested to increase
mortality in older institutionalized patients. Less is known about
the prognostic value of drugs with anticholinergic properties
(DAPs), opioids and proton-pump inhibitors (PPI). The prognostic
value of antipsychotics, DAPs, PPIs and opioids was investigated
among all institutionalized residents in Helsinki.