European Geriatric Medicine - Supplement 1 - Volume 6 - September 2015

101 / 210

Poster presentations / European Geriatric Medicine 6S1 (2015) S32–S156 S93
Methods: Older adults in the UK with sarcopenia, i.e. SPPB: 4–9
and low skeletal muscle mass index (SMI), a subset of the PROVIDE
study population (NTR2329), were matched 1:1 by age and sex to
healthy adults (SPPB≥11 and normal SMI) (n =132, 71±4 y). Muscle
mass, physical function (SPPB), hand grip strength, Quality-of-Life
(QoL), physical activity level and dietary intake were measured in
both groups. Between-group comparisons were made by matched
pairs using a paired t-test or Wilcoxon signed rank test.
Results: Muscle mass, strength, and function, QoL and physical
activity level were significantly lower in the sarcopenic adults
(p < 0.001). While energy intakes were similar (sarcopenic,
1709± 418; healthy, 1745± 513kcal/day), the sarcopenic group
consumed less protein/kg (−6%), vitamin D (−36%), vitamin B-12
(−22%), magnesium (−14%), phosphorus (−10%), and selenium
(−12%) (p < 0.05) than the healthy controls.
Conclusions: Sarcopenia significantly impacted, by definition,
muscle mass, strength and function in age-matched older adults,
also influencing QoL and activity level. Differences in dietary
nutrient intakes might be involved in causing the differences in
muscle mass, strength and function between the two groups. These
potential nutrient shortages could be addressed using a specific
oral nutritional supplement.
Disclosure of Interest: The project is sponsored by Nutricia
Research, Nutricia Advanced Medical Nutrition
P-230
A low caloric, leucine-enriched whey protein oral nutritional
supplement affects body composition in sarcopenic older
adults
S. Verlaan1,2 , S. Wijers3, J. Bauer4, C.C. Sieber5 , T. Cederholm6 , The
Provide E study group
1Nutricia Research, Utrecht, Netherlands; 2VU University Medical
Center, Amsterdam, Netherlands; 3 Nutricia Research, Nutricia
Advanced Medical Nutrition, Utrecht, Netherlands; 4 Carl von
Ossietszky University, Oldenburg, Germany; 5 Friedrich-Alexander
Universit¨at Erlangen-N¨urnberg, Nuremberg, Germany; 6Uppsala
University, Uppsala, Sweden
Rationale: High protein intake is recommended for sarcopenic
geriatric patients. Here we present the impact of supplementation
with a low caloric, fast-digestible, leucine-enriched whey protein
oral nutritional supplement.
Methods: Non-protein-energy malnourished sarcopenic older
adults (n = 380, mean±SD: 77±7 y), i.e. SPPB: 4–9, were randomly
allocated to a 150 kcal, leucine-enriched whey protein oral
nutritional supplement or an iso-caloric control product for 13
weeks (secondary analyses of PROVIDE study, NTR2329). Outcomes
included energy and protein intake, and body composition. Analyses
were made using a t-test or Mann–Whitney test (changes from
baseline are presented).
Results: Median protein intake at baseline was 1.0 g/kg body
weight/day [IQR 0.8–1.2]. In the active group, median protein intake
including the supplement increased to 1.5 g/kg/day [IQR 1.3–1.7,
p < 0.001]; whereas, there was a slight decrease of 0.05 g/kg/day
in the control group [IQR −0.2, 0.1, p = 0.012]. The intervention
led to a significant increase in body weight in control and
active groups (1.08±1.66 kg and 0.92±1.74 kg, p <0.001), driven
by fat mass (+0.78±1.20 kg, p < 0.001) in the control group
and fat (+0.40 ±1.16 kg, p < 0.001) and appendicular muscle mass
(+0.24±0.74 kg, p = 0.003) in the active group.
Conclusion: Low caloric, high protein oral nutritional supplements
are a feasible option to improve protein intake in non-protein-
energy malnourished elderly. Supplementation with this low
caloric, leucine-enriched whey protein oral nutritional supplement
resulted in a muscle mass gain and a modest increase in body
weight.
Disclosure of Interest: The project is sponsored by Nutricia
Research, Nutricia Advanced Medical Nutrition
P-231
Prevalence of sarcopenia in Parkinson’s disease
D.L. Vetrano1 , M.S. Pisciotta1, V. Brandi2 , M.R. Lo Monaco3 ,
A. Laudisio4 , G. Onder5, R. Bernabei5 , G. Zuccala1
1Catholic University – Rome, Rome, Italy; 2Italy; 3 Universit`a Cattolica
del Sacro Cuore, Roma, Italy; 4Campus Biomedico – Rome, Rome,
Italy; 5Catholic University of the Sacred Heart, Rome, Italy
Objectives: Parkinson’s disease (PD) is characterized by progressive
impairment in several domains, potentially leading to a state of
frailty. Motor and non-motor symptoms affect their independence,
performance and nutritional state. These same conditions represent
risk factors for sarcopenia. Scanty evidence is today available on
the prevalence of sarcopenia in PD. Aim of the present study was
to assess the prevalence of sarcopenia according to three different
criteria in PD patients. Their concordance was also investigated.
Methods: Data on 184 PD patients have been analysed. Skeletal
muscle mass was assessed by DXA (Dual X-Ray Absorbimetry),
muscle strength by hand grip and physical performance by 4-
meter walking speed test. EWGSOP (European Working Group on
Sarcopenia in Older People), FNIH (Foundation for the National
Institutes of Health) Sarcopenia Project and IWG (International
Working Group) criteria have been used to define sarcopenia.
Agreement was assessed by the Cohen’s k coefficient.
Results: Within participants (mean age 74 years; 36% women), the
highest prevalence of sarcopenia was found applying the EWGSOP
criteria (40.2% in men and 22.4% in women) and the lowest with the
FNIH ones (21.4% in men, 19.4% in women). Agreement was good
between EWGSOP and IWG criteria (k=0.73–0.75) and weak among
the others. In general we found high negative percent agreement
but poor positive percent agreement.
Conclusions: Sarcopenia is prevalent in older adults with PD,
with significant differences across genders and different criteria.
Agreement among criteria was scarce. Which criterion detects more
frail and impaired PD patients remains an open question.
P-232
Assessing sarcopenia in older hospitalized patients. Feasibility
and prevalence estimates of the EWGSOP algorithm
S. Volpato1 , P. Abete2, G. Bellelli3, L. Bianchi4, M. Bo5, A. Cherubini6 ,
F. Corica7, M. Maggio 4, M. Zamboni8 , F. Landi9
1University of Ferrara, Italy, Ferrara, Italy; 2University of Naples
“Federico II”, Naples, Italy; 3University of Milan, Milan, Italy; 4Italy;
5University of Turin, Italy, Turin, Italy; 6 IRCCS INRCA, Ancona, Italy;
7University of Messina, Messina, Italy; 8University of Verona, Italy;
9Catholic University of Sacred Hearth, Rome, Italy
Introduction. The term “sarcopenia” is commonly used in
the literature, but there is no agreement on the diagnostic
definition. Consequently, the prevalence of sarcopenia varies greatly
depending upon the criteria used and study setting. We investigated
the feasibility of the European Working Group on Sarcopenia
in Older People (EWGSOP) algorithm assessment in hospitalized
older adults and analyzed prevalence and clinical correlates of
sarcopenia.
Methods: Cross sectional analysis of 485 participants enrolled in a
multicenter observational study of older adults admitted to 9 acute
care wards in Italy. Sarcopenia was assessed as low skeletal mass
index (Kg/m2) plus either low hand-grip strength or low walking
speed (EWGSOP criteria). Skeletal muscle mass was estimated using
bioimpedance analysis.
Results: Of the 485 patients (age 80.7 ±6.6 years; women 48%)
enrolled in the study, 195 (40.2%) were not able to perform the
4-meter walking test and 34 (7%) did not perform the hand-grip
test because of medical problems. After exclusion of 29 patients