45 / 210
Poster presentations / European Geriatric Medicine 6S1 (2015) S32
–
S156
S37
than 80 years old, from January 2003 to December 2012. Survival
curves and the median survival times were estimated by the
Kaplan–Meier method and any significant differences between the
two groups were evaluated by the Log rank test. The authors and
coauthors have no conflict of interest to disclose.
Results:
All cases were 52 cases including male 25 cases, female 27
cases, median age was 82 years. Pathological findings, Hodgkin’s
lymphoma 2 cases, non-Hodgkin’s lymphoma(NHL) 50 cases, in
NHL,diffuse large B cell lymphoma (DLBCL) 32 cases, intravascular
large B cell lymphoma 2 cases, peripheral T cell type 3 cases
and others 15 cases (10 diagnosises). Therapy policy for NHL,
curative chemotherapy(CTx) 43 cases, palliative CTx 3 cases,
curative radiation therapy(RTx) 1 cases, palliative RTx 1 cases, best
supporting care(BSC) 4 cases. Kind of therapy, CHOP or CHOP like
therapy were 14 cases, RCHOPor RCHOP like therapy were 27 cases,
AVD therapy 1 case, C-MOPP therapy 1 case, RTx alone 2 cases,
other CTx 3 cases, BSC 4 cases. In DLBCL, median survival time was
51.1%, 5 years overall survival time was 51.2%.
Conclusions:
Even if elderly patients, especially 80 years old
patients, it is not necessary to give up to cure.
P-020
Syndrome of inappropriate secretion of antidiuretic hormone
during induction therapy for lymphoma
N. Kazuhiko
1
, D. Nagase
1
, S. Ishihara
1
, Y. Mitsui
1
, A. Sakai
1
,
Y. Kuraishi
1
, H. Izumi
1
1
Toho University Medical Center Hematology & Oncology, Oota-ku,
Japan
Objectives:
Hyponatremia is electrolyte abnormality to be often
found to inpatients. Frequency of hyponatremia Grade3 or more is
around 3.7% who received chemotherapy with 3.7%. We reported 3
cases that hyponatremia is detected during treatment of the non-
Hodgkin’s lymphoma, and were diagnosed with Syndrome of inap-
propriate secretion of antidiuretic hormone (SIADH) of the elderly.
Methods:
The subjects were 572 patients who were diagnosed as
malignant lymphomafrom January 2003 to December 2014. Criteria
of hyponatremia is evaluated in accordance with the National
Cancer Institute Common Terminology Criteria for adverse Events
(version 4.0). We investigated more than 70 years old cases.
Results:
The patients who were diagnosed SIADH, 3 patients
were more than 70 years, including male 1 case, female 2 cases,
histopathological findings, 2 cases were non-Hodgkin’s lymphoma
diffuse large B cell type, 1 case was adult T cell lymphoma.
2 received R-CHOP therapy and 1 received mLSG15. There was
multiple first manifestation in each case, general fatigue 2 cases,
appetite loss 3 cases, nausea 1 case. The time when it presented
hyponatremia, all cases presented after first course of induction
therapy. The treatment followed fluid restriction or 3% hypertonic
saline infusion and lead to rapid and efficient correction of both
clinical symptoms and plasma sodium level. We were able to
perform next course without postponing it.
Conclusions:
We can accomplish chemotherapy without changing
schedule if we discover it early and are adjusted.
P-021
Hyponatremia in non-Hodgkin’s lymphoma diffuse large B
cell type of the elderly
N. Kazuhiko
1
, S. Ishihara
2
, D. Nagase
1
, Y. Mitsui
1
, A. Sakai
1
,
Y. Kuraishi
1
, H. Izumi
1
1
Toho University Medical Center Hematology & Oncology, Oota-ku,
Japan;
2
Toho University Medical Center, Oota-ku, Japan
Objectives:
Hyponatremia is very popular complication with
hospitalized patients. In malignancies, hyponatremia sometime
lead to poor prognosis. So we investigated hyponatremia patients
in non-Hodgkin’s lymphoma diffuse large B cell lymphoma (NHL
DLBCL) of the elderly.
Methods:
The subjects in this study were 141 patients who
were treated with combination chemotherapy including rituximab
who were histopathologically diagnosed as NHL DLBCL from
January 2003 to December 2012. Criteria of hyponatremia is
evaluated in accordance with the National Cancer Institute Common
Terminology Criteria for adverse Events (version 3.0). Survival
curves and the median survival times were estimated by the
Kaplan–Meier method and any significant differences between the
two groups were evaluated by the Log rank test. The authors and
coauthors have no conflict of interest to disclose.
Results:
Hyponatremia cases were 78 cases including male 41 cases,
female 37 cases, median age was 71 years. We separated 141 cases
in 3 groups, that were normal serum Na level, hyponatremia before
chemotherapy (CTx), and hyponatremia after CTx, CRR were 81%,
51.9%, 74.5% respectively, 5 years overall survival (OS) rate were
61.8%, 61.9%, 73.5% respectively. It seemed that hyponatremia before
CTx group were poor risk group, but there were not significant
differences about OS time in 3 groups.
Conclusions:
Some authors suggested that hyponatremia led to
poor prognosis. Our study indicated that hyponatremia before
chemotherapy led to low CR rate.
P-022
Primary central nerve system lymphoma of the elderly
N. Kazuhiko
1
, D. Nagase
2
, S. Ishihara
2
, Y. Mitsui
1
, A. Sakai
1
,
Y. Kuraishi
1
, H. Izumi
1
1
Toho University Medical Center Hematology & Oncology, Oota-ku,
Japan;
2
Toho University Medical Center, Oota-ku, Japan
Objectives:
Primary central nerve system lymphoma (PCNSL) is less
than 1% of all non-Hodgkin’s lymphoma(NHL). PCNSL accounts for
2–4% of extra nodal lymphoma. We report that we reviewed CNS
lymphoma which we experienced in our department.
Methods:
From 2003 to 2013, period of 10 years, we intended for
446 patients whom malignant lymphoma was diagnosed in detail
by histopathology. We targeted more than 65 years old patients.
Clinical stage is determinded by Ann Aobor classification. And we
investigate about PCNSL cases and studied age, gender, pathological
findings, clinical stage, therapy, prognosis.
Results:
All cases were 11 cases including 8 cases that age was more
than 65 years. 1 case was relapse cases. In 7 cases, male 6 cases,
female 1 case, median age was 72 years (ranged 65 to 75 years),
all cases were NHL, 6 cases were diffuse large B cell lymphoma,1
case Burkitt lymphoma. About Humman immunodeficiency virus
(HIV) infection, there were no patient that infected HIV. The policy
of therapy end point were 6 cases cure and 1 case palliative, in
6 cases, high dose methotrexate were 3 cases, radiation therapy
alone 2 cases, radiation therapy + methotrexate 1 cases. Median
survival time was 5 months.
Conclusions:
The risk factor of PCNSL is only human
immunodeficiency virus infection. About 3,600 times are easy
to come to develop in comparison with the non-infectee. PCNS
lymphoma of the elderly were poor prognosis even if Japan PCNS
case was not related HIV infection.
P-023
Incidence of hospital falls in the geriatric inpatient population
in 2013 and 2014 at Mayo Clinic Hospital, Phoenix, Arizona, USA
E. Lew
1
, B. Corbett
2
1
Mayo Clinic, Phoenix, United States of America;
2
Mayo Clinic, hoenix,
United States of America
Hospital falls is a potentially preventable morbidity with
unfavorable sequelae. We recently conducted a two year
retrospective study on the incidence of geriatric inpatient falls
in two separate medical units at Mayo Clinic Hospital in Phoenix,
Arizona between 2013 through 2014.