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Late-breaking abstracts / European Geriatric Medicine 6S1 (2015) S177
–
S187
S187
First, most countries do not practice the registration of
geroprotective (health promotion, disease prevention) therapies.
In general, very there are not many examples of the therapies
used to prevent non-communicable disease, despite the growing
amount of biomedical research in this field. The pharmaceutical and
biomedical companies have to register geroprotective therapies as
treatments for specific diseases, which adds the cost and diminishes
the market share.
Secondly, clinical trials for geroprotective therapies might take
longer to demonstrate the effect than those for most medicines,
which risks to make such clinical trials prohibitively expensive.
Thirdly, some likely geroprotective substances are registered as
supplements which limits their medical use.
Consequently, addressing the health challenges of aging requires
revisiting the approaches to the legal status of geroprotective
substances and therapies, their development, registration and use
in clinical practice.
Conclusion:
Greater advocacy efforts should be put into the
promoting the research on ageing prevention, gerontology and
geriatrics.
P-487
Physical activity patterns and mortality risk in older persons
N. Van Schoor
1
, K. Swart
2
, D. Deeg
2
, M. Visser
2
, P. Lips
2
1
Department of Epidemiology and Biostatistics, EMGO Institute for
Health and Care Research, VU University Medical Center, Amsterdam,
Netherlands;
2
VU University Medical Center, Amsterdam, Netherlands
Objectives:
Patterns of physical activity levels over time are largely
unknown in older persons. The current study aims to identify
patterns of physical activity, their prevalence, and their association
with mortality risk in a representative population of older persons.
Methods:
Data from 1700 participants from the Longitudinal Aging
Study Amsterdam were used (mean age 71.8 years). Self-reported
physical activity was assessed at baseline in 1995–96, and at 3
and 6 years follow-up. Physical activity patterns during 6 years
were determined using K-means cluster analysis, separately among
survivors and diseased. In addition, subsequent 10-year mortality
risk was assessed in persons still alive at 6 years.
Results:
Eight physical activity patterns were distinguished. The
majority (55.3%) had a stable activity pattern: almost 30.2% was
inactive at all three time points, 19.5% was moderately active, and
5.6% was active. The remaining persons changed their physical
activity level (26.3%), or died during the 6 years of follow-up
(18.4%). After adjustment for age, sex, smoking, chronic disease
and functional limitations, subsequent 10-year mortality risk was
lower in persons who were increasingly active (HR = 0.69, 95% CI
0.48–1.00) as compared with stably inactive persons. For the
other activity patterns, no statistically significant associations with
mortality risk were observed as compared with the stable patterns.
Conclusions:
This study showed a high rate of stable inactivity in
Dutch older persons. Increasing one’s activity pattern in older age
appears to reduce mortality risk.
The authors report no financial disclosures.
P-488
Active tuberculosis in patients over 65 years old
J. Nieto L ´opez-Guerrero
1
, J.F. Pascual Pareja
2
, M. Martinez Prieto
2
,
R. Carrillo Gomez
2
, C. Garcia-Cerrada
2
, A. Noguerado Asensio
2
1
Hospital de La Paz, Spain;
2
Cantoblanco-La Paz Hospital, Madrid,
Spain
Objectives:
To assess the presentation and therapeutic response
of active tuberculosis in patients 65 or over compared to those
under 65.
Material and Method:
A retrospective observational study was
carried out, including patients, diagnosed with active tuberculosis,
attended to in the IMIU between Jan/2002 and Dec/2011, excluding
those with multirresistant tuberculosis.
Demographic characteristics, risks factors and location for TB,
comorbidities, diagnosed method, presence of resistances, and
treatment were compared. A multivariable analysis was made by
means of logistic regression in order to establish the association
of age 65 or older with the unfavourable evolution of tuberculosis,
adjusted to gender, comorbidity and HIV infection.
Results:
Those aged 65 presented a higher proportion of males
with more comorbidities and contrary those under 65 presented a
higher frequency of indigence, percentage of foreigners, background
of previous contact with TB and more HIV infection.
Amongst those patients with PTB 71.6% of those aged 65 had
baciloscopy (+) in relation with 81.3% of those under; however
there were no differences in the outputs of the culture: 91.9% in
patients aged 65 in relation with 93.1% in those under.
A multivariable analysis adjusted to age, gender, comorbidity and
HIV infection, proved that being 65 or over was associated with
unfavourable development of TB.
Conclusions:
Patients with an active TB aged 65 in our series are
more frequently male, Spaniards and present higher comorbidities
except with HIV infection. Even though pulmonary TB is the more
frequent form of presentation, oftenly has added extrapulmonary
involvement and the sputum smear is not as profitable as in those
under 65.